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HERPES B VIRUS (Herpesvirus simiae): 1997-1999


Following is a list of videotapes on the Herpes B Virus which are available for borrowing from the Audiovisual Archives of the Wisconsin Primate Research Center. Contact Ray Hamel, Special Collections Librarian: E-mail:, Telephone: 1-608-263-3512, Fax: 1-608-263-4031

VT0105 Herpesvirus Diseases in Primates

VT0158 PT. 1: Practical Methodology: Nonhuman Primate, Part I - Personnel Safety, Primate Handling and Restraint

VT0253 Risk and Management of Herpes B Virus Infection in Monkey Handlers

VT0304 PART 1 The Gross Morbid Anatomy of Diseases of Animals: Diseases of Primates

VT0345 Exotic Pet Seminar: Primates



Beale AJ David Magrath Memorial lecture: Lessons learned from the development of poliovaccines. DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION 95: 3-9, 1998.

Bennett AM; Slomka MJ; Brown DWG; Lloyd G; Mackett M Protection against herpes B virus infection in rabbits with a recombinant vaccinia virus expressing glycoprotein D. JOURNAL OF MEDICAL VIROLOGY 57(1): 47-56, 1999.

Bielitzki JT Emerging viral diseases of nonhuman primates. Pp. 377-382 in ZOO & WILD ANIMAL MEDICINE: CURRENT THERAPY. 4TH ED. Fowler ME, ed. Philadelphia, WB Saunders, 1999. (ISBN 0721686648)

Black, D H; Eberle, R Detection and differentiation of primate alpha-herpesviruses by PCR. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION 9(3): 225-231, 1997.

Blewett EL; Saliki JT; Eberle R Development of a competitive ELISA for detection of primates infected with monkey B virus (Herpesvirus simiae). JOURNAL OF VIROLOGICAL METHODS 77(1): 59-67, 1999.

Brack M Zoonoses of nonhuman primates: A review. Pp. 25-41 in EUROPEAN ASSOCIATION OF ZOO AND WILDLIFE VETERINARIANS (EAZWV) AND THE BRITISH VETERINARY ZOOLOGICAL SOCIETY (BVZS): SECOND SCIENTIFIC MEETING, MAY 21-24, 1998. , ed. Houten, Netherlands, VanSetten Kwardraat, 1998. (German & English summary)

Brown, D W G Threat to humans from virus infections of non-human primates. REVIEWS IN MEDICAL VIROLOGY 7(4): 239-246, 1997.

Buchl, S J; Keeling, M E; Voss, W R Establishing specific pathogen-free (SPF) nonhuman primate colonies. ILAR [INST LAB ANIM RESOUR] JOURNAL 38(1): 22-27, 1997.

Burich A; Hilliard JK; Weigler BJ The existence of differing monkey B virus genotypes with possible implications for degree of virulence in humans. LABORATORY ANIMAL SCIENCE 49(1): 10-11, 1999. (Review & commentary)

Carlson, C S; O'Sullivan, M G; Jayo, M J; Anderson, D K; Harber, E S; Jerome, W G; Bullock, B C; Heberling, R L Fatal disseminated cercopithecine herpesvirus 1 (herpes B) infection in cynomolgus monkeys (Macaca fascicularis). VETERINARY PATHOLOGY 34(5): 405-414, 1997.

Committee on Occupational Safety and Health in Research Animal Facilities; Institute of Laboratory Animal Resources; Commission on Life Sciences; National Research Council Washington, DC, National Academy Press, 1997, xii, 154 pp. (ISBN 0309052998)

Desrosiers, R C The value of specific pathogen-free rhesus monkey breeding colonies for AIDS research. AIDS RESEARCH AND HUMAN RETROVIRUSES 13(1): 5-6, 1997. (Letter)

Dollinger P; Brack M; Furley CW; Moisson P; Schoenbaum M; Whitney RA; Witt CJ Development of an OIE international animal health code: Recommendation on zoonoses transmissible from non-human primates. Pp. 113-120 in EUROPEAN ASSOCIATION OF ZOO AND WILDLIFE VETERINARIANS (EAZWV) AND THE BRITISH VETERINARY ZOOLOGICAL SOCIETY (BVZS): SECOND SCIENTIFIC MEETING, MAY 21-24, 1998. , ed. Houten, Netherlands, VanSetten Kwardraat, 1998. (German & English summary)

Florence, G [Herpes B: A major zoonosis transmitted by macaques.] POINT VETERINAIRE 28(186): 1761-1764 (or 67-70), 1997. (French w/ English summary)

Guly, C To breed or not to breed? Health Canada faces a monkey dilemma. CANADIAN MEDICAL ASSOCIATION JOURNAL 157(9): 1192, 1997.

Hill DJ; Langley RL; Morrow WM Occupational injuries and illnesses reported by zoo veterinarians in the United States. JOURNAL OF ZOO AND WILDLIFE MEDICINE 29(4): 371-385, 1998.

Ialeggio, D M Practical medicine of primate pets. Pp. 264-270 in PRACTICAL EXOTIC ANIMAL MEDICINE. K.L. Rosenthal, ed. Trenton, NJ, Veterinary Learning Systems, 1997. (ISBN 1-884254-33-0)

Jainkittivong A; Langlais RP Herpes B virus infection. ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS 85(4): 399-403, 1998.

Johnson-Delaney, C A Nontraditional animals for contact with immunosuppressed people: Precautions against zoonotic disease transmission. AAZV [AM ASSOC ZOO VET] ANNUAL CONFERENCE PROCEEDINGS (1997): 100-106, 1997.

Kalter, S S; Heberling, R L; Cooke, A W; Barry, J D; Tian, P Y; Northam, W J Viral infection of nonhuman primates. LABORATORY ANIMAL SCIENCE 47(5): 461-467, 1997.

Kennedy, R C; Shearer, M H; Hildebrand, W Nonhuman primate models to evaluate vaccine safety and immunogenicity. VACCINE 15(8): 903-908, 1997.

Klots IN; Rezikyan SA; Indzhiya LV; Chalyan VG; Meishvili NV; Lapin BA [Development of a method for creating a colony of Macaca mulatta, free of herpes B virus infection.] ZHURNAL MIKROBIOLOGII, EPIDEMIOLOGII I IMMUNOBIOLOGII (3): 67-68, 1998. (Russain w/ English summary)

Lamborn C OSHA levies citations and fines on Yerkes. LAB ANIMAL 27(6): 10, 1998.

Lamborn C OSHA and Yerkes reach settlement over employee death. LAB ANIMAL 28(2): 11, 1999.

Lamborn, C Yerkes plagued by B-virus scare. LAB ANIMAL 27(2): 10, 1998.

Maurin-Blanchet H [Primates for biomedical research: Discovery of a controlled supply of cynomolgus in Mauritius.] PRIMATOLOGIE. 1: 547-556, 1998. (French)

Michaels MG Xenotransplant-associated infections. LABORATORY ANIMAL SCIENCE 48(3): 228-233, 1998.

Nasto, B Germ-free monkeys advance the war against AIDS. NCRR [NAT CTR RES RESOUR] REPORTER 21(3): 12-13, 1997.

National Center for Research Resources COMPARATIVE MEDICINE RESOURCES: A RESEARCH RESOURCES DIRECTORY. Bethesda, NCRR/NIH, 1997, 94 pp.

Nisslein T; Hunsmann G Viral diseases in nonhuman primates. PRIMATE REPORT 49: 23-30, 1997.

Ostrowski SR; Leslie MJ; Parrott T; Abelt S; Piercy PE B-virus from pet macaque monkeys: An emerging threat in the United States? EMERGING INFECTIOUS DISEASES 4(1): 117-121, 1998.

Palevitz BA; Lewis R Death raises safety issues for primate handlers. SCIENTIST 12(5): 1 & 4, 1998.

Parrott, T Y An introduction to diseases of nonhuman primates. Pp. 258-263 in PRACTICAL EXOTIC ANIMAL MEDICINE. K.L. Rosenthal, ed. Trenton, NJ, Veterinary Learning Systems, 1997. (ISBN 1-884254-33-0)

Sato H; Arikawa J; Furuya M; Kitoh J; Mannen K; Nishimune Y; Ohsawa K; Serikawa T; Shibahara T; Watanabe Y; Yagami K; Yamamoto H; Yoshikawa Y Prevalence of herpes B virus antibody in nonhuman primates reared at the National University of Japan. EXPERIMENTAL ANIMALS 47(3): 199-202, 1998.

Smith AL; Black DH; Eberle R Molecular evidence for distinct genotypes of monkey B virus (Herpesvirus simiae) which are related to the macaque host species. JOURNAL OF VIROLOGY 72(11): 9224-9232, 1998.

Takasaka M; Narita T; Mukai R [Establishing an SPF colony of cynomolgus monkeys.] TPC NEWS 17(1): 17-21, 1998.

Weiss RA Retroviral zoonoses. NATURE MEDICINE 4(4): 391-392, 1998.

Whitley, R J B virus. Pp. 139-145 in INFECTIONS OF THE CENTRAL NERVOUS SYSTEM, 2ND ED. W.M. Scheld; R.J. Whitley; D.T. Durack, eds. Philadelphia, Lippincott-Raven Publ, 1997. (ISBN 0-397-51696-7)

Whitley, R J; Chapman, L Cercopithecine herpes virus 1 (B virus). Pp. 411-419 in CLINICAL VIROLOGY. D.D. Richman; R.J. Whitley; F.G. Hayden, eds. New York, Churchill Livingstone, 1997. (ISBN 0-443-07653-7)

Wolfe ND; Escalante AA; Karesh WB; Kilbourn A; Spielman A; Lal AA Wild primate populations in emerging infectious disease research: The missing link? EMERGING INFECTIOUS DISEASES 4(2): 149-158, 1998.

Anonymous Herpes B death at Yerkes. LABORATORY PRIMATE NEWSLETTER 37(1): 29, 1998.

Anonymous Fatal Cercopithecine herpesvirus 1 (B virus) infection following a mucocutaneous exposure and interim recommendation for worker protection. MMWR [MORBID MORTAL WKLY REP] 47(49): 1073-1076 & 1083, 1998.

Anonymous Yerkes/Emory settle OSHA case. LABORATORY PRIMATE NEWSLETTER 38(1): 30, 1999.

Anonymous. High percentage of Herpes B in imported monkeys. IPPL NEWS 25(1): 8, 1998.

Anonymous. Herpes B tragedy at Yerkes. IPPL NEWS 25(1): 8, 1998.


NOTE: Dr. Julia Hilliard has published some important papers on this topic and we are appending a bibliography of her work since 1986 to the regular Primate Information Center Topics search.

Burich A; Hilliard JK; Weigler BJ The existence of differing monkey B virus genotypes with possible implications for degree of virulence in humans. LABORATORY ANIMAL SCIENCE 49(1): 10-11, 1999. (Review & commentary)

Line, S W; Kaplan, J R; Heise, E R; Hilliard, J K; Cohen, S; Rabin, B S; Manuck, S B Effects of social reorganization on cellular immunity in male cynomolgus monkeys. AMERICAN JOURNAL OF PRIMATOLOGY 39(4): 235-249, 1996.

Holmes, G P ; Chapman, L E ; Stewart, J A ; Straus, S E ; Hilliard, J K ; Davenport, D S Guidelines for the prevention and treatment of B-virus infections in exposed persons. CLINICAL INFECTIOUS DISEASES 20(2): 421-439, 1995.

Weigler, B J ; Hilliard, J K Letters to the editor [Herpes B]. LAB ANIMAL 24(5): 53, 1995. (Letter & reply)

Weigler, B J ; Scinicariello, F ; Hilliard, J K Risk of venereal B virus (cercopithecine herpesvirus 1) transmission in rhesus monkeys using molecular epidemiology. JOURNAL OF INFECTIOUS DISEASES 171(5): 1139-1143, 1995.

Freifeld, A G ; Hilliard, J ; Southers, J ; Murray, M ; Savarese, B ; Schmitt, J M ; Straus, S E A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes B virus infection. JOURNAL OF INFECTIOUS DISEASES 171(4): 1031-1034, 1995.

Hilliard, J K; Ward, J A A virus specific-pathogen-free breeding colonies of macaques: Case histories of animals tested in the fifth year. LABORATORY ANIMAL SCIENCE 45(4): 454 1995. (Abstract) Reprinted in: Contemp Top Lab Anim Sci 34(4): 45-46, 1995.

Eberle, R; Hilliard, J The simian herpesviruses. INFECTIOUS AGENTS AND DISEASE 4(2): 55-70, 1995.

Ward, J A ; Hilliard, J K B virus-specific pathogen-free (SPF) breeding colonies of macaques: Issues, surveillance, and results in 1992. LABORATORY ANIMAL SCIENCE 44(3): 222-228, 1994.

Weigler, B J ; Scinicariello, F ; Hilliard, J K Risk of venereal B virus transmission in rhesus monkeys (Macaca mulatta) through use of molecular epidemiology. LABORATORY ANIMAL SCIENCE 44(4): 405, 1994. (Abstract) Reprinted in: Contemp Top Lab Anim Sci 33(4): A12, 1994.

Davenport, D S ; Johnson, D R ; Holmes, G P ; Jewett, D A ; Ross, S C ; Hilliard, J K Diagnosis and management of human B virus (Herpesvirus simiae) infections in Michigan. CLINICAL INFECTIOUS DIESEASES 19(1): 33-41, 1994.

Hilliard, J K ; Ward, J A B virus specific pathogen-free breeding colonies of macaques: Retrospective study of four years of surveillance. CONGRESS OF THE INTERNATIONAL PRIMATOLOGICAL SOCIETY 15: 195, 1994. (Abstract)

Scinicariello, F ; Eberle, R ; Hilliard, J K Rapid detection of B virus (Herpesvirus simiae) DNA by polymerase chain reaction. JOURNAL OF INFECTIOUS DISEASES 168(3): 747-750, 1993.

Weier, E C ; Bhatt, P N ; Jacoby, R O ; Hilliard, J K ; Morgenstern, S Infrequent shedding and transmission of Herpesvirus simiae from seropositive macaques. LABORATORY ANIMAL SCIENCE 43(6): 541-544, 1993.

Chellman, G J ; Lukas, V S ; Eugui, E M ; Altera, K P ; Almquist, S J ; Hilliard, J K Activation of B virus (Herpesvirus simiae) in chronically immunosuppressed cynomolgus monkeys. LABORATORY ANIMAL SCIENCE 42(2): 146-151, 1992.

Blasdel, T L ; Lipper, S L ; Hilliard, J K Medical alert card for macaque handlers. CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE 31(4): 37, 1992. (Abstract)

Hilliard, J K ; Lipper, S L ; War, J Herpes B virus: Issues, surveillance and results. Pp. 50-51 in XIVTH CONGRESS OF THE INTERNATIONAL PRIMATOLOGICAL SOCIETY. Strasbourg, IPS, 1992. (Abstract)

Ward, J A ; Farrar, R P ; Hilliard, J K Automated screening of Western Blot densitometer scans the identification of primate B virus antibodies. Pp. 105 in XIVTH CONGRESS OF THE INTERNATIONAL PRIMATOLOGICAL SOCIETY. Strasbourg, IPS, 1992. (Abstract)

Artenstein, A W ; Hicks, C B ; Goodwin, B S , Jr ; Hilliard, J K Human infection with B virus following a needlestick injury. REVIEWS OF INFECTIOUS DISEASES 13(2): 288-291, 1991.

Voss, W R ; Buchl, S J ; Keeling, M E ; Hilliard, J ; et al Derivation strategy for establishing a Macaca mulatta (rhesus) colony specifically pathogen-free of herpes B virus and simian retrovirus. AALAS BULLETIN 30(4): 18-19, 1991. (Abstract)

Janda, D H ; Ringler, D H ; Hilliard, J K ; Hankin, R C ; Hankin, F M Nonhuman primate bites. JOURNAL OF ORTHOPAEDIC RESEARCH 8(1): 146-150, 1990.

Kessler, M J ; Hilliard, J K Seroprevalance of B virus (Herpesvirus simiae) antibodies in a naturally formed group of rhesus macaques. JOURNAL OF MEDICAL PRIMATOLOGY 19(2): 155-160, 1990.

Weigler, B J ; Roberts, J A ; Hird, D W ; Lerche, N W ; Hilliard, J K A cross sectional survey for B virus antibody in a colony of group housed rhesus macaques. LABORATORY ANIMAL SCIENCE 40(3): 257-261, 1990.

Nanda, M ; Curtin, V T ; Hilliard, J K ; Bernstein, N D ; Dix, R D Ocular histopathologic findings in a case of human herpes B virus infection. ARCHIVES OF OPHTHALMOLOGY 108(5): 713-716, 1990.

Holmes, G P ; Hilliard, J K ; Klontz, K C ; Rupert, A H ; Schindler, C M ; Parrish, E ; Griffin, D G ; Ward, G S ; Bernstein, N D ; Bean, T W ; Ball, M R , Sr ; Brady, J A ; Wilder, M H ; Kaplan, J E B virus (Herpesvirus simiae) infection in humans: Epidemiologic investigation of a cluster. ANNALS OF INTERNAL MEDICINE 112(11): 833-839, 1990.

Weir, E C ; Bhatt, P N ; Hilliard, J K ; Morgenstern, S E ; et al Absence of transmission and excretion of Herpesvirus simiae from seropositive macaques. LABORATORY ANIMAL SCIENCE 40(5): 549, 1990. (Abstract)

Eberle, R ; Hilliard, J K Serological evidence for variation in the incidence of herpesvirus infections in different species of apes. JOURNAL OF CLINICAL MICROBIOLOGY 27(6): 1357-1366, 1989.

Kessler, M J ; London, W T ; Madden, D L ; Dambrosia, J M ; Hilliard, J K ; Soike, K F ; Rawlins, R G Serological survey for viral diseases in the Cayo Santiago rhesus macaque population. PUERTO RICO HEALTH SCIENCES JOURNAL 8(1): 95-97, 1989.

Kessler, M J ; London, W T ; Rawlins, R G ; Hilliard, J K ; et al Viral serosurvey of the Cayo Santiago macaques. AMERICAN JOURNAL OF PRIMATOLOGY 18(2): 151, 1989. (Abstract)

Benson, P M ; Malane, S L ; Banks, R ; Hicks, C B ; Hilliard, J B virus (Herpesvirus simiae) and human infection. ARCHIVES OF DERMATOLOGY 125(9): 1247-1248, 1989.

Wells, D L ; Lipper, S L ; Hilliard, J K ; Stewart, J A ; Holmes, G P ; Herrmann, K L ; Kiley, M P ; Schonberger, L B Herpesvirus simiae contamination of primary rhesus monkey kidney cell cultures. CDC recommendations to minimize risks to laboratory personnel. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 12(4): 333-336, 1989.

Rosenberg, D P ; Hilliard, J ; Butler, T M Occupational hazard of B-virus disease. LABORATORY ANIMAL SCIENCE 38(4): 491, 1988. (Abstract)


Hilliard, J K ; Eberle, R ; Lipper, S L ; Munoz, R M ; Weiss, S A Herpesvirus simiae (B virus): Replication of the virus and identification of viral polypeptides in infected cells. ARCHIVES OF VIROLOGY 93(3-4): 185-198, 1987.

Hilliard, J K ; Munoz, R M ; Lipper, S L ; Eberle, R Rapid identification of herpesvirus simiae (B virus) DNA from clinical isolates in nonhuman primate colonies. JOURNAL OF VIROLOGICAL METHODS 13(1): 55-62, 1986.

Katz, D ; Hilliard, J K ; Eberle, R ; Lipper, S L ELISA for detection of group-common and virus-specific antibodies in human and simian sera induced by herpes simplex and related simian viruses. JOURNAL OF VIROLOGICAL METHODS 14(2): 99-109, 1986.

In cooperation with the Washington Regional Primate Research Center, Primate-Science offers bi-monthly searches of recent literature on a range of nonhuman primate topics. The source for these searches is the Primates database of the Primate Information Center, part of the Washington Regional Primate Research Center and the University of Washington Health Science Libraries, Seattle, Washington. If you would like to be able to access this database, see the instructions below for obtaining a password. Suggestions for topics for this series should be sent to Jackie Pritchard, Primate Information Center Manager, e-mail: or Larry Jacobsen, PIN Coordinator, e-mail:



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