Primate Info Net Banner Wisconsin PRC Logo

Current Topics in Primatology
Primate Information Center
Washington Regional Primate Research Center



Macaca Clinical Chemistry (Normative, Baseline or Control Values): 1995 - 2000

[Note from Jackie Pritchard,  PIC:  This bibliography is a bit 
heterogeneous from titles, but often good clinical chemistry is found in 
toxicological studies where they have baseline or control values.]


Akahori, H; Shibuya, K; Obuchi, M; Nishizawa, Y; Tsuji, A;
Kabaya, K; Kusaka, M; Ohashi, H; Tsumura, H; Kato, T;
Miyazaki, H
Effect of recombinant human thrombopoietin in nonhuman
primates with chemotherapy-induced thrombocytopenia.
BRITISH JOURNAL OF HAEMATOLOGY 94(4): 722-728, 1996.

Anderson, W I ; Smiler, K L ; Leopard, D M ; Bell, R M
Hepatic granulomas in a female cynomolgus monkey (Macaca
fascicularis): Schistosomiasis. LAB ANIMAL 24(1): 17-19,
1995.

Atzpodien, E; Mehdi, N; Clarke, D; Radhofer-Welte, S
Subacute and chronic oral toxicity of lornoxicam in
cynomolgus monkeys.
FOOD AND CHEMICAL TOXICOLOGY 35(5): 465-474, 1997.

Brann T; Kayda D; Lyons RM; Shirley P; Roy S; Kaleko M;
Smith T
Adenoviral vector-mediated expression of physiologic levels
of human factor VIII in nonhuman primates.
HUMAN GENE THERAPY 10(18): 2999-3011, 1999.

Buchl, S J; Howard, B
Hematologic and serum biochemical and electrolyte values in
clinically normal domestically bred rhesus monkeys (Macaca
mulatta) according to age, sex and gravidity. LABORATORY
ANIMAL SCIENCE 47(5): 528-533, 1997.

Buttar, H S ; Fournier, J ; LeBlanc, C
Studies on the biochemical composition of maternal plasma
and amniotic fluid of the cynomolgus monkey. TERATOLOGY
51(3): 179, 1995. (Abstract)

Buttar, H S; Moffat, J H; Fournier, J
Comparison of the biochemical profiles of maternal plasma
and amniotic fluid of rat and monkey. TERATOLOGY 53(2): 107,
1996. (Abstract)

Champoux, M; Kriete, M F; Higley, J D; Suomi, S J
CBC and serum chemistry differences between Indian-derived
and Chinese-Indian hybrid rhesus monkey infants.
AMERICAN JOURNAL OF PRIMATOLOGY 39(1): 79-84, 1996.

Chevalier, G; Benard, P; Durand, S; Verschuere, B; et al
Plasma biochemical parameters in Mauritian long-tailed
macaques.
FOLIA PRIMATOLOGICA 69(1): 52, 1998. (Abstract)

Colman RJ; Kemnitz JW; Lane MA; Abbott DH; Binkley N
Skeletal effects of aging and menopausal status in female
rhesus macaques.
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(11):
4144-4148, 1999.

Durand, S; Chevalier, G; Verschuere, B; Bengone, T; et al
Plasma lipid parameters in Macaca fascicularis bred in
Mauritius:  A biochemical study. FOLIA PRIMATOLOGICA 69(1):
54, 1998. (Abstract)

Durand, S; Morelli, A; Verschuere, B; Pourrut, X; et al
Study of several blood parameters in long tailed macaques
from Mauritius.
FOLIA PRIMATOLOGICA 67(2): 90, 1996. (Abstract)

Gentz, E J; Carpenter, J W
Clinical challenge--case 2:  [Bloat].
JOURNAL OF ZOO AND WILDLIFE MEDICINE 26(1): 164-166, 1995.

Goodrich, J A ; Ward, G S ; Swindle, M M
Normal serum biochemical and hematological values of the
Sulawesi macaques. JOURNAL OF MEDICAL PRIMATOLOGY 24(1):
17-28, 1995.

Gu CH; Yuan BJ; Lu GC; Dai ZR; Liu JP; Zhang SY; Zhang P;
Jiang CL
Long-term toxicity of modified recombinant human tumor
necrosis factor in Macaca mulatta. ZHONGGUO YAOLI XUEBAO /
ACTA PHARMACOL SIN 19(1): 85-88, 1998.

Ha JC; Nosbisch C; Abkowitz JL; Conrad SH; Mottet NK;
Ruppenthal GC; Robinette R; Sackett GP; Unadkat JD
Fetal, infant, and maternal toxicity of zidovudine
(azidothymidine) administered throughout pregnancy in Macaca
nemestrina.
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN
RETROVIROLOGY 18(1): 27-38, 1998.

Hasselschwert DL; Ostrowski SR
An atypical case of Mycobacterium bovis in a cynomolgus
macaque (Macaca fascicularis) imported from the Philippines.
CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE 38(6):
36-38, 1999.

Hausen B; Gummert J; Berry GJ; Christians U; Serkova N;
Ikonen T; Hook L; Legay F; Schuler W; Schreier MH; Morris RE
Prevention of acute allograft rejection in nonhuman primate
lung transplant recipients - Induction with chimeric
anti-interleukin-2 receptor monoclonal antibody improves the
tolerability and potentiates the immunosuppressive activity
of a regimen using low doses of both microemulsion
cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin.
TRANSPLANTATION 69(4): 488-496, 2000.

Hausen B; Ikonen T; Briffa N; Berry GJ; Christians U;
Robbins RC; Hook L; Serkova N; Benet LZ; Schuler W; Morris
RE
Combined immunosuppression with cyclosporine (Neoral) and
SDZ RAD in non-human primate lung transplantation:
Systematic pharmacokinetic-based trials to improve efficacy
and tolerability. TRANSPLANTATION 69(1): 76-86, 2000.

Hendrickx, A G ; Dukelow, W R
Breeding. Pp. 335-374 in NONHUMAN PRIMATES IN BIOMEDICAL
RESEARCH. B.T. Bennett; C.R. Abee; R. Henrickson, eds. San
Diego, Academic Press, 1995.

Henry, S P; Bolte, H; Auletta, C; Kornbrust, D J
Evaluation of the toxicity of ISIS 2302, a phosphorothioate
oligonucleotide, in a four-week study in cynomolgus monkeys.
TOXICOLOGY 120(2): 145-155, 1997.

Hodge, J W; Schlom, J; Donohue, S J; Tomaszewski, J E;
Wheeler, C W; Levine, B S; Gritz, L; Panicali, D; Kantor, J
A
A recombinant vaccinia virus expressing human
prostate-specific antigen (PSA):  Safety and immunogenicity
in a non-human primate.
INTERNATIONAL JOURNAL OF CANCER 63(2): 231-237, 1995.

Hollinger, M A
Appendices:  Tables of toxicological importance.
Pp. 771-920 in CRC HANDBOOK OF TOXICOLOGY. M.J. Derelanko;
M.A. Hollinger, eds. Boca Raton, CRC Press, 1995.

Hom GJ; Bach TJ; Carroll D; Forrest MJ; Mariano MA; Trainor
CE; Wang PR; Macintyre DE
Comparison of cardiovascular parameters and/or serum
chemistry and hematology profiles in conscious and
anesthetized rhesus monkeys (Macaca mulatta). CONTEMPORARY
TOPICS IN LABORATORY ANIMAL SCIENCE 38(2): 60-64, 1999.

Hrapkiewicz K; Medina L; Holmes DD
CLINICAL LABORATORY ANIMAL MEDICINE: AN INTRODUCTION. 2ND
ED. Ames, Iowa State Univ Press, 1998, x, 277 pp..

Ikeda, H; Okasaki, K; Sameshima, H; Nagata, R
Background data on infant cynomolgus monkeys:  Hematology
and serum biochemistry tests. JOURNAL OF TOXICOLOGICAL
SCIENCES 21(5): 406, 1996. (Abstract)

Ivester, K ; Dittmer, E C, eds
PRIMATE CARE.
Tucson, Simian Soc of Amer, Inc, 1995, 281 pp.

Jennings, V M; Dillehay, D L; Webb, S K
Diagnostic exercise:  Hepatomegaly in an aged cynomolgus
(Macaca fascicularis) monkey. LABORATORY ANIMAL SCIENCE
45(6): 680-682, 1995.

Jerome CP; Johnson CS; Vafai HT; Kaplan KC; Bailey J;
Capwell B; Fraser F; Hansen L; Ramsay H; Shadoan M; Lees CJ;
Thomsen JS; Mosekilde L
Effect of treatment for 6 months with human parathyroid
hormone (1- 34) peptide in ovariectomized cynomolgus monkeys
(Macaca fascicularis).
BONE 25(3): 301-309, 1999.

Koizumi, H; Nakanishi, H; Suzuki, S; Hirata, M
[Four-week oral toxicity study on NK433 in cynomolgus
monkeys.]
JITCHUKEN ZENRINSHO KENKYU HO/ PRECLIN REP CENT INST EXP
ANIM 20(1): 37-54, 1995.  (Japanese w/ English summary)

Koizumi, H; Nakanishi, H; Suzuki, S; Hirata, M
[Twenty-six oral toxicity study on NK433 in cynomolgus
monkeys.]
JITCHUKEN ZENRINSHO KENKYU HO/ PRECLIN REP CENT INST EXP
ANIM 20(1): 55-68, 1995. (Japanese w/ English summary)

Kung, A H C ; Cavagnaro, J A ; Makin, A ; White, M A ; Kong,
K N
Toxicologic evaluations of an immunotoxin, H65-RTA.
FUNDAMENTAL AND APPLIED TOXICOLOGY 26(1): 75-84, 1995.

Lees CJ; Ramsay H
Histomorphometry and bone biomarkers in cynomolgus females:
A study in young, mature, and old monkeys. BONE 24(1):
25-28, 1999.

Levine, B S
Animal clinical pathology.
Pp. 517-537 in CRC HANDBOOK OF TOXICOLOGY. M.J. Derelanko;
M.A. Hollinger, eds. Boca Raton, CRC Press, 1995.

Lewis, J H
COMPARATIVE HEMOSTASIS IN VERTEBRATES.
New York, Plenum Press, 1996, xx, 426 pp.

Litwak KN; Cefalu WT; Wagner JD
Chronic hyperglycemia increases arterial low-density
lipoprotein metabolism and atherosclerosis in cynomolgus
monkeys.
METABOLISM - CLINICAL AND EXPERIMENTAL 47(8): 947-954, 1998.

Murray, S; Tell, L A; Bush, M
Zinc toxicosis in a Celebes ape (Macaca nigra) following
ingestion of pennies.
JOURNAL OF ZOO AND WILDLIFE MEDICINE 28(1): 101-104, 1997.

Nagai A; Kawamura Y; Kodama T; Onimaru T
[Thirteen-week intravenous repeated dose toxicity study of
T-3762, a novel parenteral quinolone antimicrobial agent,
and four-week recovery test in cynomolgus monkeys.] JAPANESE
JOURNAL OF ANTIBIOTICS 51(11): 625-681, 1998. (Japanese w/
English summary)

Nagai A; Shibata T; Nagasawa M; Shiotani N; Miyazaki M;
Kawamura Y; Kodama T; Onimaru T
[Single dose intravenous toxicity studies of T-3762, a novel
parenteral quinolone antimicrobial agent, in rats, dogs and
monkeys.]
JAPANESE JOURNAL OF ANTIBIOTICS 51(10): 583-599, 1998.
(Japanese w/ English summary)

Nakamura E; Lane MA; Roth GS; Ingram DK
A strategy for identifying biomarkers of aging: Further
evaluation of hematology and blood chemistry data from a
calorie restriction study in rhesus monkeys. EXPERIMENTAL
GERONTOLOGY 33(5): 421-443, 1998.

Newton, P E
Inhalation toxicology.
Pp. 217-276 in CRC HANDBOOK OF TOXICOLOGY. M.J. Derelanko;
M.A. Hollinger, eds. Boca Raton, CRC Press, 1995.

Ohno, H; Crome, S J; Genda, Y; Furuhama, K; Nomura, M;
Onodera, T
[Toxicity of iodixanol, a new nonionic iso-osmolar contrast
medium, to cynomolgus monkeys by repeated intravenous
administration for 4 weeks with a 4-week recovery period.]
JOURNAL OF TOXICOLOGICAL SCIENCES 20(Suppl 1): 87-105, 1995.
(Japanese w/ English summary)

Okasaki K; Katsutani N; Sagami F; Yamatsu K
[A 13-week repeated intravenous dose toxicity study with
cefluprenam followed by a 5-week recovery period in
cynomolgus monkeys.]
YAKURI TO CHIRYO/ JPN PHARMACOL THER 25(Suppl 6): 171-196
(or S1319-S1344), 1997.

Okasaki K; Ohnishi M; Samejima H; Katsutani N; Sagami F;
Shionoya H; Yamatsu K
[A 4-week repeated intravenous dose toxicity study of
cefluprenam followed by a 4-week recovery period in
cynomolgus monkeys.]
YAKURI TO CHIRYO/ JPN PHARMACOL THER 25(Suppl 6): 121-145
(or S1269-S1293), 1997.

Orlando, L; Renoldi, A; Peano, S; Vigna, E; Maraschin, R;
Komatsu, S
Thirteen-week repeated intramuscular dose toxicity study of
SJ-0021 (r-hFSH) in monkeys. YAKURI TO CHIRYO/ JPN PHARMACOL
THER 23(8): 1913-1951 (or 93-113), 1995.

Poleschuk VF; Titova IP; Balayan MS; Sobol AV; Gulyaeva TV;
Dokin VP
Blood biochemical data in Saguinus mystax, Callithrix
jacchus and Macaca fascicularis used in experiments with
viral hepatitis.
PRIMATE REPORT (50): 63-65, 1998.

Ramachandra SG; Ramesh V; Krishnamurthy HN; Ravindranath N;
Shetty KT
Normal hematological and plasma biochemical parameters of
the captive bonnet monkey (Macaca radiata). PRIMATES 39(2):
127-137, 1998.

Rao, A J; Ravindranath, N; Moudgal, N R
The plant Banjauri (Vicoa indica) exhibits antifertility
activity in adult female bonnet monkeys (Macaca radiata).
CURRENT SCIENCE 7(11): 918-921, 1996.

Renoldi, A; Vigna, E; Peano, S; Orlando, L; Maraschin, R;
Komatsu, S
Four-week repeated intramuscular dose toxicity studies of
SJ-0021 (r-hFSH) in monkeys. YAKURI TO CHIRYO/ JPN PHARMACOL
THER 23(8): 1889-1991 (or 51-73), 1995.

Rice, D C
Effect of long-term lead exposure on hematology, blood
biochemistry, and growth curves in monkeys. NEUROTOXICOLOGY
18(1): 221-236, 1997.
Erratum:  18(2): 606.

Sato, N; Kiuchi, K; Shen, Y-T; Vatner, S F; Vatner, D E
Adrenergic responsiveness is reduced, while baseline cardiac
function is preserved in old adult conscious monkeys.
AMERICAN JOURNAL OF PHYSIOLOGY 269(5, pt 2): H1664-H1671,
1995.

Short, R; Williams, D D; Bowden, D M
Circulating antioxidants as determinants of the rate of
biological aging in pigtailed macaques (Macaca nemestrina).
JOURNAL OF GERONTOLOGY 52A(1): B26-B38, 1997.

Svensson, E C; Black, H B; Dugger, D L; Tripathy, S K;
Goldwasser, E; Hao, Z-p; Chu, L-e; Leiden, J M
Long-term erythropoietin expression in rodents and non-human
primates following intramuscular injection of a
replication-defective adenoviral vector.
HUMAN GENE THERAPY 8(15): 1797-1806, 1997.

Takayama, S; Sieber, S M; Adamson, R H; Thorgeirsson, U P;
Dalgard, D W; Arnold, L L; Cano, M; Eklund, S; Cohen, S M
Long-term feeding of sodium saccharin to nonhuman primates:
Implications for urinary tract cancer.
JOURNAL OF THE NATIONAL CANCER INSTITUTE 90(1): 19-25, 1998.

Tanaka, S; Narita, H; Ohtoh, K; Yoshida, T; Cho, F;
Yoshikawa, Y
[Obesity and scrawny in female cynomolgus monkeys (Macaca
fascicularis): Their relation to hematological and serum
biochemical properties.]
SEICHO/ J GROWTH 34(2): 43-48, 1995. (Japanese w/ English
summary)

Tarantal AF; Marthas ML; Shaw JP; Cundy K; Bischofberger N
Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine
(PMPA) to gravid and infant rhesus macaques (Macaca
mulatta): Safety and efficacy studies. JOURNAL OF ACQUIRED
IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY 20(4):
323-333, 1999.

Tsarev, S A ; Tsareva, T S ; Emerson, S U ; Rippy, M K ;
Zack, P ; Shapiro, M ; Purcell, R H
Experimental hepatitis E in pregnant rhesus monkeys:
Failure to transmit hepatitis E virus (HEV) to offspring and
evidence of naturally acquired antibodies to HEV. JOURNAL OF
INFECTIOUS DISEASES 172(1): 31-37, 1995.

Uckun FM; Ek O; Liu XP; Chen CL
In vivo toxicity and pharmacokinetic features of the Janus
kinase 3 inhibitor WHI-P131
[4-(4'hydroxyphenyl)-amino-6,7-dimethoxyquinazoline].
CLINICAL CANCER RESEARCH 5(10): 2954-2962, 1999.

Vancata V; Privratsky V; Zlamalova H; Vancatova M; Mazura I
A longitudinal study of ontogeny of Macaca mulatta.
VARIABILITY AND EVOLUTION 7: 5-29, 1999.

Wiedmeyer CE; Morton DG; Cusick PK; Wright T; Solter PF;
Hoffmann WE
Semiautomated analysis of alkaline phosphatase isoenzymes in
serum of normal cynomolgus monkeys (Macaca fascicularis).
VETERINARY CLINICAL PATHOLOGY 28(1): 2-7, 1999.

Wilmott, R W; Amin, R S; Perez, C R; Wert, S E; Keller, G;
Boivin, G P; Hirsch, R; De Inocencio, J; Lu, P; Reising, S
F; Yei, S-p; Whitsett, J A; Trapnell, B C
Safety of adenovirus-mediated transfer of the human cystic
fibrosis transmembrane conductance regulator cDNA to the
lungs of nonhuman primates. HUMAN GENE THERAPY 7(3):
301-318, 1996.

Wolfensohn S; Lloyd M
HANDBOOK OF LABORATORY ANIMAL MANAGEMENT AND WELFARE. 2ND
ED. Oxford, Blackwell Science, 1998, 344 pp..

Woodward, R A; Weld, K P
A comparison of ketamine, ketamine-acepromazine, and
tiletamine-zolazepam on various hematologic parameters in
rhesus monkeys (Macaca mulatta).
CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE 36(3):
55-57, 1997.

Yamamoto S; Sugiyama K; Ochiai T; Danks A
[Thirteen-week intravenous toxicity study of lanoteplase
(genetical recombination) in monkeys followed by 4-week
recovery test.]
OYO YAKURI/ PHARMACOMETRICS 54(5): 285-300, 1997.

Yoshioka, M; Yamada, H; Tanaka, M; Orita, S; Sato, S
Control clinical pathologic data in rats, beagle dogs and
cynomolgus monkeys used in toxicity studies.
TAKEDA KENKYUSHO HO/J TAKEDA RES LAB 54: 154-176, 1995.
(Japanese w/ English summary)

Young, G D ; Koplovitz, I
Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF)
in rhesus monkeys:  Serum biochemical and hematologic
changes.
ARCHIVES OF TOXICOLOGY 69(6): 379-383, 1995.