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Aging in the Nervous System (Established 1970)
Director: Douglas Rosene
Mission: The Laboratory for Cognitive Neurobiology is focused on understanding the neurological basis in health and disease of higher cognitive functions including learning, memory and executive system functions.
Principal Research Programs: The main program is centered on the effects of aging in the central nervous system of the rhesus monkey, "Macaca mulatta". Monkeys are initially behaviorally tested to assess their memory and cognitive functions, after which the brains are examined to determine the structural, neurochemical and functional changes that may account for age-related cognitive impairments. Other investigations are examing the interaction of aging with untreated hypertension and with recovery from cortical stroke. Another study using behavioral, anatomical and fMRI methods examines the interaction of the prefrontal cortex and medial temporal limbic system in memory and executive system functions. Methods include behavioral testing, light and electron microscopy; immunohistochemistry, in situ hyrbidization, DT-MRI, fMRI and structural MRI and both in vivo and in vitro neuropysiology.
Training Opportunities: Educational opportunities are available for graduate studies using experimental methods. Field work opportunities not available; Program emphasis: Nervous system;
Financial Aid: Financial support for PhD students and post-doctoral fellows is available; Note: We are interested in recruiting both pre- and postdoctoral students and usually take one PhD per year.
Number of Staff: 15
Supported Species: -10 Macaca mulatta (rhesus macaque)
Last Updated: 2001-11-14
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